Synthetic Corticosteroid Drug Raw Powder Triamcinolone Acetonide
What is Triamcinolone acetonide?
Triamcinolone acetonide is a synthetic corticosteroid used topically to treat various skin conditions, to relieve the discomfort of mouth sores and intra-articularly by proceduralists to treat various joint conditions.[1] In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.
Triamcinolone acetonide Basic Information
| Product name |
Triamcinolone acetonide |
| CAS |
76-25-5 |
| Assay |
99% |
| Formula |
C24H31FO6 |
| Molecular Weight |
434.55 |
| EINECS |
200-948-7 |
| Density |
1.33 g/cm3 |
| Melting Point |
274-278°C (dec.) |
| Boiling Point |
576.9 °C at 760 mmHg |
| Flash Point |
302.7 °C |
| Appearance |
White or almost white crystalline powder |
Triamcinolone acetonide Certificate of Analysis
| Product name |
Triamcinolone Acetonide |
| CAS No. |
76-25-5 |
Outer Packing |
1kg |
| Production date |
11th Jan 2018 |
Shelf life |
10th Jan 2021 |
| Standard adopted |
EP8.0 |
| Items of analysis |
Specification |
Results |
| Appearance |
White or almost white crystalline powder |
White crystalline powder |
| Identification |
A. IR absorption B. TLC |
Conforms |
| Specific Rotation |
+ 110° ~ + 117° |
+113.6° |
| Loss On Drying |
Not more than2.0% |
0.6% |
| Impurity B |
not more than 0.2% |
0.03% |
| Impurity C |
not more than 0.15% |
0.05% |
| Single unknownl impurity |
not more than 0.1% |
0.04% |
| Total impurities |
not more than 0.5% |
0.27% |
| Methanol |
Not more than 3000ppm |
Conforms |
| Chloroform |
Not more than 60ppm |
Conforms |
| Dimethylformamide |
Not more than 880ppm |
Conforms |
| Assay |
97.0% ~ 103.0% |
100.1% |
| Conclusion |
Qualified |
Triamcinolone acetonide Medical Uses
1) Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions.
2) Triamcinolone Applied as a topical ointment, applied to the skin, it is used to mitigate blistering from poison ivy, oak, and sumac,[citation needed].
3) Triamcinolone combined with Nystatin, it is used to treat skin infections with discomfort from fungus, though it should not be used on the eyes, mouth, or genital area. It provides relatively immediate relief and is used before using oral prednisone. Oral and dental paste preparations are used for treating aphthous ulcers.
4) As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema.
