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USP38 Tetracaine Base Powder | Local Anesthetic

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  • Specifications

Manufacturer Supply 100.52% Purity USP38 Local Anesthetic Powder Tetracaine Base

 

What is Tetracaine?

Tetracaine, also known as amethocaine, is a local anesthetic used to numb the eyes, nose, or throat. Tetracaine may also be used before starting an intravenous to decrease pain from the procedure. Typically it is applied as a liquid to the area. Onset of effects when used in the eyes is within 30 seconds and last for less than 15 minutes. 

 

Tetracaine Chemical profile

CAS: 94-24-6
MF: C15H24N2O2
MW: 264.36
EINECS: 202-316-6
Assay: 99%
Quality Standards: USP38
Appearance: White or light yellow, waxy solid

 

Tetracaine Certificate Of Analysis

Items Standard Results
Description White or light yellow, waxy solid Complies
Identification A. Dissolve 100 mg in 10 mL of dilut hydrochloric acid(1 in 120), and add 1 mL of potassium thiocyanate
Solution (1 in 4): A crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: It melts between 130 and 132. 
Complies
B: By UV, To match with working standard Complies
Complies
Chromatographic purity Conform to standard Complies
Loss on drying ≤0.5% 0.09%
Resiue on ignition ≤0.1% 0.03%
Melting range 41ºC~46ºC 42.3ºC~43.6ºC
Residual Solvents Ethanol≤0.5%
Acetone≤0.5%
Dichloromethane≤0.06%
Toluene≤0.089%
Isopropyl ether≤0.5%
Not detected
Not detected
Not detected
Not detected
0.009%
Assay(*) 99.0%~101.0% 100.52%
Conclusion The Sample Complies With Specification of USP38

 

 

Tetracaine Dosing

Spinal Anesthesia
High, median, low & saddle: 0.2%-0.3% solution

For perineum: 5 mg/dose
For lower extremities: 10 mg/dose
For saddle block: 2-5 mg/dose
Prolonged (2-3 hours): 1% solution
For spinal: 1% solution diluted 1:1 in CSF, administered at 1 mL per 5 seconds
Doses of >15 mg are rarely required, and should only be used in exceptional cases

Ophthalmic
Short term anesthesia: 1-2 gtt into affected eye just prior to evaluation

Minor surgical procedure: 1-2 gtt into affected eye q5-10min
Prolonged surgical procedure: 1-2 gtt into affected eye q5-10min; not to exceed 5 doses

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