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Levobupivacaine Hydrochloride Hcl Powder | Raw Local Anesthetic

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Buy Levobupivacaine Hydrochloride Raw Powder Levobupivacaine Hcl Source

 

What is Levobupivacaine Hydrochloride?

Levobupivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine.

The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

 

Levobupivacaine Hydrochloride Basic Info

Name Articaine hydrochloride
CAS No. 23964-57-0
Formula C13H20N2O3S.HCl
Molecular Weight 320.84
EINECS 245-957-7
Boiling Point 440.6 °C at 760 mmHg
Flash Point 220.3 °C
Appearance white powder
Application local anesthetic(Oral use)

 

Levobupivacaine Hydrochloride Application

Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.

 

Levobupivacaine Hydrochloride Certificate Of Analysis

Product Name Levobupivacaine hydrochloride
Batch . 15061201 Mfg. date 2018.01.03
Approval Date 2018.01.03 Date of Expiry 2020.01.01
Results Of Analysis Tests
Test Analysis Standard Results
Character White or off-white crystalline powder, smell-less. Soluble in the ethanol freely, in the chloroform slightly, and soluble in the water or 0.01mol/L HCl Complies
Identification 1) Separate out the yellow deposition 2) There is the max absorbance between 263nm to 271 nm wavelength. Complies
Acidity(PH) 4.5~6.0 4.7
Total impurity Not more than 0.5% 0.17%
Optical isomers Not more than 0.5% N.D
Loss on drying Not more than 1.0% 0.21%
Burnt residue Not more than 0.1% 0.05%
Heavy metals Not more than 20ppm Complies
Ferric salt Not more than 0.001% Complies
[α]20D -11.0°~-14° -12.4°
Assay 98.5%( calculated on the anhydrous basis.) 99.30%
Conclusion Be Conform With Enterprise Standard

 

Levobupivacaine VS Bupivacaine

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

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